Leveraging The Potential Of Personality Traits For Digital Health Interventions : A Literature Review On Digital Markers For Conscientiousness And Neurotism

Digital health interventions (DHIs) are designed to help individuals manage their disease, such as asthma, diabetes, or major depression. While there is a broad body of literature on how to design evidence- based DHIs with respect to behavioral theories, behavior change techniques or various design features, targeting personality traits has been neglected so far in DHI designs, although there is evidence of their impact on health. In particular, conscientiousness, which is related to therapy adherence, and neuroticism, which impacts long-term health of chronic patients, are two personality traits with an impact on health. Sensing these traits via digital markers from online and smartphone data sources and providing corresponding personality change interventions, i.e. to increase conscientiousness and to reduce neuroticism, may be an important active and generic ingredient for various DHIs. As a first step towards this novel class of personality change DHIs, we conducted a systematic literature review on relevant digital markers related to conscientiousness and neuroticism. Overall, 344 articles were reviewed and 21 were selected for further analysis. We found various digital markers for conscientiousness and neuroticism and discuss them with respect to future work, i.e. the design and evaluation of personality change DHIs

Computerassistierte Präzisionschirurgie am Ohr

Chirurgische Eingriffe am Ohr stellen aufgrund der komplexen Anatomie und der Grössenverhältnisse der beteiligten anatomischen Strukturen eine Herausforderung für den HNO-Chirurgen dar. In diesem Beitrag wird ein Ansatz für die roboterbasierte Navigation zur Hörgeräteimplantation vorgestellt. Insbesondere wird auf die Möglichkeit des Fräsens von Implantatlagern im Felsenbein eingegangen. Je präziser ein Implantat im Schädel verankert werden kann, desto einfacher ist der chirurgischen Ablauf. Weiterhin, profitieren Patienten von verkürzten Operationszeiten und weniger schmerzhaften Eingriffe

Radiation dose optimization in pediatric temporal bone computed tomography: influence of tube tension on image contrast and image quality

Introduction: The purpose of this experimental study was to investigate the effect of tube tension reduction on image contrast and image quality in pediatric temporal bone computed tomography (CT). Methods: Seven lamb heads with infant-equivalent sizes were scanned repeatedly, using four tube tensions from 140 to 80kV while the CT-Dose Index (CTDI) was held constant. Scanning was repeated with four CTDI values from 30 to 3mGy. Image contrast was calculated for the middle ear as the Hounsfield unit (HU) difference between bone and air and for the inner ear as the HU difference between bone and fluid. The influence of tube tension on high-contrast detail delineation was evaluated using a phantom. The subjective image quality of eight middle and inner ear structures was assessed using a 4-point scale (scores 1-2 = insufficient; scores 3-4 = sufficient). Results: Middle and inner ear contrast showed a near linear increase with tube tension reduction (r = −0.94/−0.88) and was highest at 80kV. Tube tension had no influence on spatial resolution. Subjective image quality analysis showed significantly better scoring at lower tube tensions, with highest image quality at 80kV. However, image quality improvement was most relevant for low-dose scans. Conclusions: Image contrast in the temporal bone is significantly higher at low tube tensions, leading to a better subjective image quality. Highest contrast and best quality were found at 80kV. This image quality improvement might be utilized to further reduce the radiation dose in pediatric low-dose CT protocol

The Effects of Health Care Chatbot Personas With Different Social Roles on the Client-Chatbot Bond and Usage Intentions: Development of a Design Codebook and Web-Based Study

Background The working alliance refers to an important relationship quality between health professionals and clients that robustly links to treatment success. Recent research shows that clients can develop an affective bond with chatbots. However, few research studies have investigated whether this perceived relationship is affected by the social roles of differing closeness a chatbot can impersonate and by allowing users to choose the social role of a chatbot. Objective This study aimed at understanding how the social role of a chatbot can be expressed using a set of interpersonal closeness cues and examining how these social roles affect clients’ experiences and the development of an affective bond with the chatbot, depending on clients’ characteristics (ie, age and gender) and whether they can freely choose a chatbot’s social role. Methods Informed by the social role theory and the social response theory, we developed a design codebook for chatbots with different social roles along an interpersonal closeness continuum. Based on this codebook, we manipulated a fictitious health care chatbot to impersonate one of four distinct social roles common in health care settings—institution, expert, peer, and dialogical self—and examined effects on perceived affective bond and usage intentions in a web-based lab study. The study included a total of 251 participants, whose mean age was 41.15 (SD 13.87) years; 57.0% (143/251) of the participants were female. Participants were either randomly assigned to one of the chatbot conditions (no choice: n=202, 80.5%) or could freely choose to interact with one of these chatbot personas (free choice: n=49, 19.5%). Separate multivariate analyses of variance were performed to analyze differences (1) between the chatbot personas within the no-choice group and (2) between the no-choice and the free-choice groups. Results While the main effect of the chatbot persona on affective bond and usage intentions was insignificant (P=.87), we found differences based on participants’ demographic profiles: main effects for gender (P=.04, ηp2=0.115) and age (P<.001, ηp2=0.192) and a significant interaction effect of persona and age (P=.01, ηp2=0.102). Participants younger than 40 years reported higher scores for affective bond and usage intentions for the interpersonally more distant expert and institution chatbots; participants 40 years or older reported higher outcomes for the closer peer and dialogical-self chatbots. The option to freely choose a persona significantly benefited perceptions of the peer chatbot further (eg, free-choice group affective bond: mean 5.28, SD 0.89; no-choice group affective bond: mean 4.54, SD 1.10; P=.003, ηp2=0.117). Conclusions Manipulating a chatbot’s social role is a possible avenue for health care chatbot designers to tailor clients’ chatbot experiences using user-specific demographic factors and to improve clients’ perceptions and behavioral intentions toward the chatbot. Our results also emphasize the benefits of letting clients freely choose between chatbots

How Is Variety in Daily Life Related to the Expression of Personality States? An Ambulatory Assessment Study

People differ in the way they live their daily lives. For some people, daily life is characterized by multiple and diverse experiences, while others have more stability and routine in their lives. However, little is known about how variety in daily life relates to the expression of personality states. The present study examined within-person associations between variety in social partners, places, and activities with state expression. Data came from an ambulatory assessment study (N = 962, Mage = 25.49) with four assessments per day over a period of six consecutive days. The results of the multilevel modeling analyses suggest that variety in daily life is associated with some, but not all, state expressions. For instance, on days when participants experienced a greater variety in activities, they reported being less neurotic and conscientious, but also more agreeable. In addition, the links between all social partners, places, and activities with the expression of the state were examined simultaneously to obtain more detailed information on the multifaceted nature of situation-state expression links. We conclude that variety in daily life has both theoretical and empirical relevance for the expression of personality states

Personality change through a digital-coaching intervention: Using measurement invariance testing to distinguish between trait domain, facet, and nuance change

Recent intervention research has shown that personality traits can be modified through psychological interventions. However, it is unclear whether reported effects represent changes in the trait domain or only some facets or items. Using data ( N = 552) from a recent intervention trial, the present study examined the effects of a digital-coaching intervention on self- and observer-reported personality facets and items. We focused on participants who wanted to decrease in Negative Emotionality, increase in Conscientiousness or increase in Extraversion. We used measurement invariance testing to examine which level of the trait domain hierarchy changed during the intervention. For the self-reports, we found some heterogeneity in the effects on all three trait domains, but most notably Extraversion and Conscientiousness. Specifically, participants reported to increase strongly on sociability (Extraversion), and moderately on productiveness and organization (Conscientiousness), but not on the other facets of these trait domains. Observers generally reported small but non-significant changes, with no scalar invariance violations except for Extraversion. Overall, this suggests considerable heterogeneity in intervention-related personality change that can be overlooked if only focusing on the trait domain level. We discuss the relevance of measurement invariance testing and measurement approaches for personality development and intervention research

Personality change through a digital-coaching intervention: Using measurement invariance testing to distinguish between trait domain, facet, and nuance change

Recent intervention research has shown that personality traits can be modified through psychological interventions. However, it is unclear whether reported effects represent changes in the trait domain or only some facets or items. Using data ( N = 552) from a recent intervention trial, the present study examined the effects of a digital-coaching intervention on self- and observer-reported personality facets and items. We focused on participants who wanted to decrease in Negative Emotionality, increase in Conscientiousness or increase in Extraversion. We used measurement invariance testing to examine which level of the trait domain hierarchy changed during the intervention. For the self-reports, we found some heterogeneity in the effects on all three trait domains, but most notably Extraversion and Conscientiousness. Specifically, participants reported to increase strongly on sociability (Extraversion), and moderately on productiveness and organization (Conscientiousness), but not on the other facets of these trait domains. Observers generally reported small but non-significant changes, with no scalar invariance violations except for Extraversion. Overall, this suggests considerable heterogeneity in intervention-related personality change that can be overlooked if only focusing on the trait domain level. We discuss the relevance of measurement invariance testing and measurement approaches for personality development and intervention research

Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans

Garlic extracts have been shown to decrease drug exposure for saquinavir, a P-glycoprotein and cytochrome P450 3A4 substrate. In order to explore the underlying mechanisms and to study the effects of garlic on pre-systemic drug elimination, healthy volunteers were administered garlic extract for 21 days. Prior to and at the end of this period, expression of duodenal P-glycoprotein and cytochrome P450 3A4 protein were assayed and normalized to villin, while hepatic cytochrome P450 3A4 function and simvastatin, pravastatin and saquinavir pharmacokinetics were also evaluated. Ingestion of garlic extract increased expression of duodenal P-glycoprotein to 131% (95% CI, 105-163%), without increasing the expression of cytochrome P450 3A4 which amounted to 87% (95% CI, 67-112%), relative to baseline in both cases. For the erythromycin breath test performed, the average result was 96% (95% CI, 83-112%). Ingestion of garlic extract had no effect on drug and metabolite AUCs following a single dose of simvastatin or pravastatin, although the average area under the plasma concentration curve (AUC) of saquinavir decreased to 85% (95% CI, 66-109%), and changes in intestinal P-glycoprotein expression negatively correlated with this change. In conclusion, garlic extract induces intestinal expression of P-glycoprotein independent of cytochrome P450 3A4 in human intestine and liver

A scalable monitoring for the CMS Filter Farm based on elasticsearch

A flexible monitoring system has been designed for the CMS File-based Filter Farm making use of modern data mining and analytics components. All the metadata and monitoring information concerning data flow and execution of the HLT are generated locally in the form of small documents using the JSON encoding. These documents are indexed into a hierarchy of elasticsearch (es) clusters along with process and system log information. Elasticsearch is a search server based on Apache Lucene. It provides a distributed, multitenant-capable search and aggregation engine. Since es is schema-free, any new information can be added seamlessly and the unstructured information can be queried in non-predetermined ways. The leaf es clusters consist of the very same nodes that form the Filter Farm thus providing natural horizontal scaling. A separate central" es cluster is used to collect and index aggregated information. The fine-grained information, all the way to individual processes, remains available in the leaf clusters. The central es cluster provides quasi-real-time high-level monitoring information to any kind of client. Historical data can be retrieved to analyse past problems or correlate them with external information. We discuss the design and performance of this system in the context of the CMS DAQ commissioning for LHC Run 2